KONTROLA KVALITETE POMOĆU VIŠEDIMENZIONALNOG MODELA GRAĐEVINE

U diplomskom radu obrađuje se tema Building Information Modelinga (BIM) te pridodavanje dodatnih dimenzija 3D modelima građevine da bi se dobio informacijski model građevine koji sadrži 6 dimenzija (3D, troškovi, vrijeme i kontrola kvalitete). Teorijski su opisane sve prednosti i mane koje BIM donosi u građevinski projekt te kakve promijene BIM donosi za sve sudionike građevinskog projekta. Obrađena je tema kontrole kvalitete pri izvođenju konstrukcija, navedena je zakonska regulativa vezana za kontrolu kvalitete pri izvedbi konstrukcija te opisane su zakonske obveze i odgovornosti koje imaju izvođač te nadzorni inženjer pri provedbi kontrole kvalitete na gradilištu. U praktičnom dijelu rada izrađen je 3D model građevine pomoću računalnog programa Revit 2015, a kasnije se po principu BIM-a uz pomoć računalnog programa GALA izrađuje troškovnik te dinamički plan izvođenja radova. Kao dimenzija informacijskom modelu građevine dodana je kontrola kvalitete.This master thesis concentrates on subject of Building Information Modeling (BIM) and adding additional dimensions to 3D model of building to get model of building that incorporates 6 dimensions (3D, cost, time and quality control). All the advantages and disadvantages that BIM brings in construction project and the changes that BIM brings for all participants of the construction project will be explained. Also subject of quality management at construction site will be defined, legislation relating to quality management at construction site are going to be mentioned and legal obligations and responsibilities that site manager and supervising engineer have when implementing quality control at building site. In second part of this master thesis first will be made 3D model of building using Revit 2015, later using BIM principals and GALA cost estimates and time schedule for constructing a building will be made. As the last of the 6 dimensions in this model quality management will be added, it will be shown 2 ways of implementing quality control by using BIM and Revit 2015

Razlike u kvaliteti života ovisnika o heroinu liječenih u metadonskom programu i ovisnika liječenih u programu terapijske zajednice

Aim of the study was comparing the quality of life of addicts treated in frame of methadone substitution programs and addicts undergoing the rehabilitation on the frame of therapeutic community. We have done a crossover study in the Center for Prevention and Out-patient Treatment in Mostar. We have included 60 subjects in our study. All of them were heroin addicts, referred to the Center for Prevention and Out-patient Treatment in Mostar, who satisfied the DSM-IV criteria for the addiction disease. The subjects have been divided in three groups: 1) group of just-admitted patients (N=20), 2) group of patients who had spent six months in methadone program (N=20) and 3) group of patient who had spent six months in the therapeutic community program (N=20). In this study, we have gathered data for social-demographic variables such as age, education, marital and professional status and variables related to the addiction, such as duration of addiction, manner of drug administration, alcohol use and presence of HCV, HBV or HIV viral infections. For the estimation of quality of life, we have used the “Quality of life index”, to measure the perception of the important areas of life, such as health and functioning in the fields of social, economic, psychological and spiritual domains. A majority of subjects from this sample had achieved the secondary school education and were of similar age, unmarried, mostly unemployed and only a smaller number of them were living alone, out of their primary families. The groups tested have not significantly differed considering those living conditions which reflect the quality of life. The results of addiction variables had showed that a majority of subjects administered the drug intravenously, there were no significant differences concerning the duration of addiction and the most of the subjects had drunk no alcohol. We have not detected any cases of HIV infection, while a significant number of subjects had been infected with hepatitis B virus. This study revealed significant differences in quality of life between the groups tested. The groups of subjects who had undergone the methadone program and the group of those treated in the frame of therapeutic community showed significantly higher scores on quality of life scales compared to the group of just-admitted patients, while there were no such differences between the group of subjects who had undergone the methadone program and the group of those treated in the frame of therapeutic community. The data obtained indicate that the methadone treatment is similarly effective concerning the quality of subjects’ life as the treatment in the frame of therapeutic communityCilj istraživanja bio je usporediti kvalitetu života ovisnika liječenih u supstitucijskom metadonskom programu i ovisnika na rehabilitaciji u terapijskoj zajednici. Provedeno je presječno istraživanje u Centru za prevenciju i izvanbolničko liječenje ovisnosti u Mostaru. U istraživanje je uključeno 60 ispitanika. Svi su ovisnici o heroinu koji su se javili u Centar za prevenciju i izvanbolničko liječenje ovisnosti u Mostaru, a koji zadovoljavaju DSM-IV kriterije za dijagnozu ovisnosti. Ispitanici su podijeljeni u tri skupine: 1) skupinu tek primljenih pacijenata (N=20), 2) skupinu pacijenata koji su proveli 6 mjeseci u metadonskom programu (N=20) i3) skupinu pacijenta koji su proveli 6 mjeseci u programu terapijske zajednice (N=20). U istraživanju su prikupljane socidemografske varijable kao što su dob, edukacija, bračni i radni status, te varijable vezane za ovisnost kao što su dužina ovisničkog staža, način uzimanja droge, uporaba alkohola te prisutnosti infekcije virusima HCV, HBV i HIV. Za procjenu kvalitete života koristio “Quality of life index” kojim se mjerila percepcija važnih životnih područja kao što su zdravlje i funkcioniranje, socijalno i ekonomsko, psihološko i spiritualno, te obiteljsko područje. Većina ispitanika u uzorku je bila srednjoškolski obrazovana, podjednake dobi, neoženjeni, najveći dio je bio bez posla, a samo mali broj je živio sam van primarne obitelji. Ispitivane skupine se nisu značajno razlikovale prema uvjetima življenja koji su pokazatelji kvalitete života. Rezultati istraživanja ovisničkih varijabli pokazuju da je većina ispitanika drogu uzimala intravenskim putem, nije bilo razlika u trajanju ovisničkog staža među skupinama, te ih većina nije pila alkohol. Nije nađen nijedan slučaj infekcije HIV-om, a veći broj ispitanika u uzorku su bili zaraženi virusom hepatitisa C, dok je vrlo mali broj ispitanika bio zaražen virusom hepatitisa B. U ovom istraživanju su nađene značajne razlike u kvaliteti života među ispitivanim skupinama. Skupine ispitanika liječenih u metadonskom programu i u programu terapijske zajednice pokazale su značajno veće rezultate na skalama kvalitete života u odnosu na skupinu tek primljenih pacijenata, a između skupine ispitanika koji su bili u metadonskom programu liječenja i skupine u terapijskoj zajednici nije bilo takvih razlika. Dobiveni podaci ukazuju na činjenicu da je liječenje metadonom podjednako djelotvorno kao i boravak u terapijskoj zajednici po utjecaju na promjene u kvaliteti života ispitanika

KONTROLA KVALITETE POMOĆU VIŠEDIMENZIONALNOG MODELA GRAĐEVINE

U diplomskom radu obrađuje se tema Building Information Modelinga (BIM) te pridodavanje dodatnih dimenzija 3D modelima građevine da bi se dobio informacijski model građevine koji sadrži 6 dimenzija (3D, troškovi, vrijeme i kontrola kvalitete). Teorijski su opisane sve prednosti i mane koje BIM donosi u građevinski projekt te kakve promijene BIM donosi za sve sudionike građevinskog projekta. Obrađena je tema kontrole kvalitete pri izvođenju konstrukcija, navedena je zakonska regulativa vezana za kontrolu kvalitete pri izvedbi konstrukcija te opisane su zakonske obveze i odgovornosti koje imaju izvođač te nadzorni inženjer pri provedbi kontrole kvalitete na gradilištu. U praktičnom dijelu rada izrađen je 3D model građevine pomoću računalnog programa Revit 2015, a kasnije se po principu BIM-a uz pomoć računalnog programa GALA izrađuje troškovnik te dinamički plan izvođenja radova. Kao dimenzija informacijskom modelu građevine dodana je kontrola kvalitete.This master thesis concentrates on subject of Building Information Modeling (BIM) and adding additional dimensions to 3D model of building to get model of building that incorporates 6 dimensions (3D, cost, time and quality control). All the advantages and disadvantages that BIM brings in construction project and the changes that BIM brings for all participants of the construction project will be explained. Also subject of quality management at construction site will be defined, legislation relating to quality management at construction site are going to be mentioned and legal obligations and responsibilities that site manager and supervising engineer have when implementing quality control at building site. In second part of this master thesis first will be made 3D model of building using Revit 2015, later using BIM principals and GALA cost estimates and time schedule for constructing a building will be made. As the last of the 6 dimensions in this model quality management will be added, it will be shown 2 ways of implementing quality control by using BIM and Revit 2015

Analysis of the Gut Microbiome and Dietary Habits in Metastatic Melanoma Patients with a Complete and Sustained Response to Immunotherapy

Immunotherapy has improved the prognosis of metastatic melanoma patients, although most patients do not achieve a complete response. While specific gut microbiome and dietary habits might influence treatment success, there is a lack of concordance between the studies, potentially due to dichotomizing patients only into responders and non-responders. The aim of this study was to elucidate whether metastatic melanoma patients with complete and sustained response to immunotherapy exhibit differences in gut microbiome composition among themselves, and whether those differences were associated with specific dietary habits. Shotgun metagenomic sequencing revealed that patients who exhibited a complete response after more than 9 months of treatment (late responders) exhibited a significantly higher beta-diversity (p = 0.02), with a higher abundance of Coprococcus comes (LDA 3.548, p = 0.010), Bifidobacterium pseudocatenulatum (LDA 3.392, p = 0.024), and lower abundance of Prevotellaceae (p = 0.04) compared to early responders. Furthermore, late responders exhibited a different diet profile, with a significantly lower intake of proteins and sweets and a higher intake of flavones (p < 0.05). The research showed that metastatic melanoma patients with a complete and sustained response to immunotherapy were a heterogeneous group. Patients with a late complete response exhibited microbiome and dietary habits which were previously associated with an improved response to immunotherapy